@article{ref1,
title="On an engaged case of cardiac arrhythmia following duloxetine intoxication",
journal="Romanian journal of legal medicine",
year="2017",
author="Buccelli, C. and Vacchiano, G. and Niola, M. and Graziano, V. and Basilicata, P. and Silvestre, A. and Pieri, M.",
volume="25",
number="1",
pages="60-64",
abstract="Background. At present, few studies have reported on acute or lethal intoxication after duloxetine ingestion; in almost all cases, the drug has been associated with other substances. <br><br>OBJECTIVE. The present paper reports the case of a 65-year-old man suffering from a psychiatric disorder, who is under treatment with Cymbalta ®. Despite no history of suicide attempts, his wife found him unresponsive in his bedroom near to an empty drug box. <br><br>RESULTS. Toxicological analyses performed on post-mortem specimens revealed the presence of duloxetine at concentrations of 3.6, 7.3 and 63.4 μg/mL in his blood, bile and gastric content, respectively, and of 1.3 and 0.5 μg/g in his liver and brain. The cause of death was ascribed to cardiac arrhythmia following duloxetine intoxication. <br><br>CONCLUSIONS. Obtained data suggest possible cardiac arrhythmia related to DLX intoxication, and confirm the wide variability of toxic/lethal duloxetine concentrations reported in the literature, as well as the hypothesis of a non-linear elimination kinetics after massive drug intake. © 2017 Romanian Society of Legal Medicine.<p /><p>Language: en</p>",
language="en",
issn="1221-8618",
doi="10.4323/rjlm.2017.60",
url="http://dx.doi.org/10.4323/rjlm.2017.60"
}