@article{ref1,
title="Clinical and epidemiological study of patients hospitalized for major depressive episode",
journal="Annales medico-psychologiques",
year="2000",
author="Montagnon, F. and Saïd, S. and Payan, C. and Corruble, E. and Taleb, M. and Rouillon, F.",
volume="158",
number="1",
pages="11-20",
abstract="We conducted a prospective study in hospitalized patients in order to evaluate the prevalence and the clinical characteristics of patients resistant to antidepressant treatment. 151 patients, fulfilling DSM-III-R criteria for major depressive episode, were included in the study; sex ratio was two women for one man and mean age was 44 years. 34% had no previous major depressive episode, 58% had melancholic features and 34% had attempted suicide. Comorbidity was high: 57%, 51% and 54% had another current diagnoses on axis I, II and III respectively. 30% were not previously treated with antidepressant. 27% were considered as resistant to antidepressant treatment: these patients were more frequently female, had a higher education level and a more severe disease with longer duration of depressive episodes, more frequent psychiatric care, high frequency of melancholic features, fewer psychosocial stress and increased TSH compared with non-resistant patients.<p /><p>Language: en</p>",
language="en",
issn="0003-4487",
doi="",
url="http://dx.doi.org/"
}