@article{ref1,
title="Post-mortem studies of brain phosphatidylinositol hydrolysis in depression and the effect of antidepressant treatment",
journal="International journal of neuropsychopharmacology",
year="2000",
author="Coull, M.A. and Lowther, S. and Katona, C.L.E. and Horton, R.W.",
volume="3",
number="2",
pages="109-115",
abstract="Basal, neurotransmitter and G protein-mediated [3H]PI hydrolysis was measured in the frontal cortex, temporal cortex, hippocampus and thalamus from suicides, with a firm retrospective diagnosis of depression, and individually matched controls. Suicides were divided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. There were no significant differences in basal, GTPγS-, 5-HT- or ACPD-stimulated [3H]PI hydrolysis in either antidepressant-free or antidepressant-treated suicides and their respective controls in the four brain regions studied. This was also the case when suicides were divided into those dying by violent or non- violent means. The two main conclusions from this study are: (i) neurotransmitter- (5-HT and ACPD) stimulated [3H]PI hydrolysis was unaltered in depression, and (ii) antidepressant treatment did not modify PI-mediated signal transduction.<p /><p>Language: en</p>",
language="en",
issn="1461-1457",
doi="10.1017/S1461145700001851",
url="http://dx.doi.org/10.1017/S1461145700001851"
}