@article{ref1,
title="Parvalbumin interneurons in human ventromedial prefrontal cortex: a comprehensive post-mortem study of myelination and perineuronal nets in neurotypical individuals and depressed suicides with and without a history of child abuse",
journal="Cerebral cortex",
year="2024",
author="Théberge, Stéphanie and Belliveau, Claudia and Xie, Dongyue and Khalaf, Roy and Perlman, Kelly and Rahimian, Reza and Davoli, Maria Antonietta and Turecki, Gustavo and Mechawar, Naguib",
volume="34",
number="5",
pages="bhae197-bhae197",
abstract="Cortical parvalbumin interneurons (PV+) are major regulators of excitatory/inhibitory information processing, and their maturation is associated with the opening of developmental critical periods (CP). Recent studies reveal that cortical PV+ axons are myelinated, and that myelination along with perineuronal net (PNN) maturation around PV+ cells is associated with the closures of CP. Although PV+ interneurons are susceptible to early-life stress, their relationship between their myelination and PNN coverage remains unexplored. This study compared the fine features of PV+ interneurons in well-characterized human post-mortem ventromedial prefrontal cortex samples (n = 31) from depressed suicides with or without a history of child abuse (CA) and matched controls. In healthy controls, 81% of all sampled PV+ interneurons displayed a myelinated axon, while a subset (66%) of these cells also displayed a PNN, proposing a relationship between both attributes. Intriguingly, a 3-fold increase in the proportion of unmyelinated PV+ interneurons with a PNN was observed in CA victims, along with greater PV-immunofluorescence intensity in myelinated PV+ cells with a PNN. This study, which is the first to provide normative data on myelination and PNNs around PV+ interneurons in human neocortex, sheds further light on the cellular and molecular consequences of early-life adversity on cortical PV+ interneurons.<p /> <p>Language: en</p>",
language="en",
issn="1047-3211",
doi="10.1093/cercor/bhae197",
url="http://dx.doi.org/10.1093/cercor/bhae197"
}