@article{ref1,
title="Altered brain protein kinase C in depression: a post-mortem study",
journal="European Neuropsychopharmacology",
year="2000",
author="Coull, M. A. and Lowther, S. and Katona, C. L. and Horton, R. W.",
volume="10",
number="4",
pages="283-288",
abstract="[(3)H]Phorbol 12,13-dibutyrate (PDBu) binding was measured in soluble and particulate fractions of frontal cortex and hippocampus from suicides, with a firm retrospective diagnosis of depression, and individually matched controls. Suicides were divided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. In frontal cortex, there was a significantly higher number (by 75%) of [(3)H]PDBu binding sites in the soluble fraction in antidepressant-free suicides compared to controls; significant differences were also seen in the proportion of sites in the soluble and particulate fractions. Higher numbers of [(3)H]PDBu binding sites in the particulate fraction of hippocampus in antidepressant-free suicides was restricted to those who died by violent means. No significant differences in the number of [(3)H]PDBu binding sites were found in antidepressant-treated suicides compared to controls. This study provides evidence for the involvement of protein kinase C in the pathophysiology of depression.<p /><p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/s0924-977x(00)00084-5",
url="http://dx.doi.org/10.1016/s0924-977x(00)00084-5"
}