@article{ref1,
title="Clinical analysis of neuropsychiatric involement in severe acute respiratory syndrome",
journal="Chinese Journal of Neurology",
year="2004",
author="Tang, Y.-m. and Xing, Y.-g. and Li, J.-g. and Ding, Y.-q. and Lei, C.-l. and Tang, X.-p.",
volume="37",
number="3",
pages="228-230",
abstract="OBJECTIVE: To investigate the clinical features of severe acute respiratory syndrome (SARS) with neuropsychiatric involement. <br><br>METHODS: The clinical data of 173 patients of SARS with neuropsychiatric involement were retrospectively reviewed. <br><br>RESULTS: (1) The incidence of neuropsychiatric involement of SARS is about 53.2%. The manifestations mostly consist of: headache 67.1% ,dizziness 28.9%, consciousness disorder 10.4%, mental disorder 4.6%, focal manifestations 0.6%, seizures 1.2%, affective disorder 30.6%, in which anxiety 20.2%, depression 6.4%, tendency of committing suicide 1.2%, phobia 7.5%. (2) The number of serious cases with neuropsychiatric involement were much more than those of slight cases, P <0.01. (3) Ophthalmoscopic examination was performed for four patients and showed that the outline of optic disc was blurred, and the retinal veins were congestive. (4) Pathological characteristics of 2 cases: edema of the perivascular tissue and vascular wall of the small veins accompanying with mononuclear cells and lymphocytes infiltration, neuron degeneration and demyelination distributing in the brain. <br><br>CONCLUSIONS: The manifestation of neuropsychiatric involement is variable, and is associated with the severity of SARS. The typical pathological change is edema, localized necrosis and neuron degeneration and demyelination.<p /><p>Language: zh</p>",
language="zh",
issn="1006-7876",
doi="",
url="http://dx.doi.org/"
}