@article{ref1,
title="Mirtazapine-associated rapid weight gain and decreased physical activity",
journal="Journal of pharmacy practice and research",
year="2004",
author="Kethini, T. and Alderman, C.P. and Doecke, C.J.",
volume="34",
number="4",
pages="308-309",
abstract="BACKGROUND: Mirtazapine-associated weight gain is widely documented. However, data demonstrating changes in physical activity associated with mirtazapine have not been published. <br><br>AIM: To describe a case of rapid weight gain and decreased physical activity associated with mirtazapine. Clinical features: A 55-year-old Caucasian man was admitted after attempting suicide and was diagnosed with post-traumatic stress disorder and depression. He was treated with mirtazapine 30 mg daily and zopiclone 15 mg at night during 5 weeks of hospitalisation and discharged on the same therapy. As a part of a research protocol, the patient was followed closely for 17 weeks after first observation, and his body weight, physical activity and biochemical parameters were recorded. Outcomes: The patient's weight increased by 10 kg within 2 weeks of starting mirtazapine, and at the end of the 17-week follow-up period the total weight gain was 17.5 kg. The fasting blood glucose and serum lipid concentrations had also increased. At the conclusion of the follow-up period, physical activity levels had decreased by 40% relative to baseline. An objective causality assessment revealed that the relationship between mirtazapine and weight gain could be regarded as possible. <br><br>CONCLUSION: Patients on mirtazapine should be monitored for changes in weight and offered information about diet and exercise to assist in weight management.<p /><p>Language: en</p>",
language="en",
issn="1445-937X",
doi="10.1002/jppr2004344308",
url="http://dx.doi.org/10.1002/jppr2004344308"
}