@article{ref1,
title="Colchicine related pancytopenia unresponsive to granulocyte colony stimulating factor",
journal="Case Reports and Clinical Practice Review",
year="2007",
author="Sedat, K. and Alper, K. and Haktan, K. and Selim, T.",
volume="8",
number="",
pages="13-15",
abstract="BACKGROUND: Colchicine overdose is uncommon but extremely serious and it is associated with considerable mortality. Previous reports have shown that granulocyte colony-stimulating factor therapy was an effective method of treating the colchicine related pancytopenia. Case Reports: We describe a case of suicidal ingestion of 15 mg of colchicine in a previously healthy 23-yearsold woman. During nasogastric tube insertion, nasal bleeding developed in the emergency room and stopped after anterior nasal tamponage. Following days, patient's platelet counts decreased to 14.9 K/UL due to bone marrow suppression. In spite of all therapeutic approach including granulocyte colony-stimulating factor, our patient died on 5th day due to severe bleeding. <br><br>CONCLUSIONS: Bone marrow suppression may be resistant to granulocyte colony-stimulating factor in colchicine poisoning. We recommend that all invasive procedures were performed more carefully in patient doubted colchicine ingestion.<p /><p>Language: en</p>",
language="en",
issn="1643-3742",
doi="",
url="http://dx.doi.org/"
}