@article{ref1,
title="Sub-acute toxicosis caused by a multiple doses tegafur/uracil (UFT) for suicide: A case report",
journal="Kitakanto medical journal",
year="2007",
author="Hagiwara, S. and Ogino, T. and Takahashi, Y. and Isaka, A. and Nameki, T. and Kagoshima, K. and Yamada, T. and Ishihara, K. and Hiraishi, H. and Kurabayashi, K. and Handa, H. and Iino, Y.",
volume="57",
number="4",
pages="317-320",
abstract="Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/uracil 9960mg) in an effort to commit suicide, and suffered from sub-acute toxicosis (main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G -CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.<p /><p>Language: en</p>",
language="en",
issn="1343-2826",
doi="10.2974/kmj.57.317",
url="http://dx.doi.org/10.2974/kmj.57.317"
}