@article{ref1,
title="Long-term event-related potential changes following organophosphorus insecticide poisoning",
journal="Clinical neurophysiology",
year="2008",
author="Dassanayake, Waidyaratne Dassanayake Mudiyanselage Tharaka Lagath and Weerasinghe, V. and Dangahadeniya, U. and Kularatne, Keerthi and Dawson, Andrew and Karalliedde, L. and Senanayake, N.",
volume="119",
number="1",
pages="144-150",
abstract="OBJECTIVE: To determine prolonged effects of organophosphorus (OP) insecticide poisoning on cognitive event-related potentials (ERPs). METHODS: ERPs of a group of 32 patients recovered from cholinergic phase of OP insecticide poisoning were compared with those of two matched control groups: 32 healthy volunteers and nine patients hospitalised with paracetamol overdose. A follow-up assessment was done in 21 patients (66% of the initial sample) 6 months after OP intoxication and the findings were compared with their initial ERP data. RESULTS: Patients showed highly significant prolongation of P300 latency, compared to healthy controls (p=0.003) and the controls with paracetamol overdose (p=0.016). Follow-up ERP findings of the patients revealed that this impairment remained unchanged even 6 months after OP poisoning (p=0.790). There was no significant difference in N100, P200 and N200 latencies or P300 amplitude either among the groups or between the two assessments of the patients with OP poisoning. CONCLUSIONS: Our results suggest that acute OP poisoning causes a delay in cognitive processes involved in stimulus classification, lasting at least for 6 months. SIGNIFICANCE: These findings highlight the possibility of development of long-lasting cognitive deficits following OP insecticide poisoning, and warrant longer-term prospective studies to determine whether this impairment is permanent.<p /> <p>Language: en</p>",
language="en",
issn="1388-2457",
doi="10.1016/j.clinph.2007.09.134",
url="http://dx.doi.org/10.1016/j.clinph.2007.09.134"
}