@article{ref1,
title="Childhood adversity and time-to-pregnancy in a preconception cohort",
journal="American journal of epidemiology",
year="2024",
author="Lovett, Sharonda M. and Orta, Olivia R. and Boynton-Jarrett, Renee and Wesselink, Amelia K. and Ncube, Collette N. and Nillni, Yael I. and Hatch, Elizabeth E. and Wise, Lauren A.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="We examined the association between childhood adversity and fecundability (the per-cycle probability of conception), and the extent to which childhood social support modified this association. We used data from 6,318 female participants aged 21-45 years in Pregnancy Study Online (PRESTO), a North American prospective preconception cohort study (2013-2022). Participants completed a baseline questionnaire, bimonthly follow-up questionnaires (until pregnancy or a censoring event), and a supplemental questionnaire on experiences across the life course including adverse childhood experiences (ACE) and social support (using the modified Berkman-Syme Social Network Index [SNI]). We used proportional probabilities regression models to compute fecundability ratios (FR) and 95% confidence intervals (CI), adjusting for potential confounders and precision variables. Adjusted FRs for ACE scores 1-3 and ≥4 vs. 0 were 0.91 (95% CI: 0.85, 0.97) and 0.84 (95% CI: 0.77, 0.91), respectively. FRs for ACE scores ≥4 vs. 0 were 0.86 (95% CI: 0.78, 0.94) among participants reporting high childhood social support (SNI ≥4) and 0.78 (95% CI: 0.56, 1.07) among participants reporting low childhood social support (SNI <4). Our findings confirm results from two previous studies and indicate that high childhood social support slightly buffered the effects of childhood adversity on fecundability.<p /> <p>Language: en</p>",
language="en",
issn="0002-9262",
doi="10.1093/aje/kwae085",
url="http://dx.doi.org/10.1093/aje/kwae085"
}