@article{ref1,
title="Mitochondrial respiratory chain activity in an animal model of mania induced by ouabain",
journal="Acta neuropsychiatrica",
year="2011",
author="Freitas, T.P. and Rezin, G.T. and Fraga, D.B. and Moretti, M. and Vieira, J.S. and Gomes, L.M. and Borges, L.S. and Valvassori, S.S. and Quevedo, J. and Streck, E.L.",
volume="23",
number="3",
pages="106-111",
abstract="OBJECTIVES: Bipolar disorder (BD) is a mental illness associated with higher rates of suicide. The present study aims to investigate the brain mitochondrial respiratory chain activity in an animal model of mania induced by ouabain. <br><br>METHODS: Adult male Wistar rats received a single intracerebroventricular administration of ouabain (10-3 and 10 -2 M) or vehicle. Locomotor activity was measured using the open field test. Mitochondrial respiratory chain activity was measured in the brain of rats 1 h and 7 days after ouabain administration. <br><br>RESULTS: Our results showed that spontaneous locomotion was increased 1 h and 7 days after ouabain administration. Complexes I, III and IV activities were increased in the prefrontal cortex, hippocampus and striatum immediately after the administration of ouabain, at the concentration of 10-3 and 10-2 M. Moreover, complex II activity was increased only in the prefrontal cortex at the concentration of 10-2 M. On the other hand, no significant alterations were observed in complex I activity 7 days after ouabain administration. However, an increase in complexes II, III and IV activities was observed only in the prefrontal cortex at the concentration of 10-2 M. <br><br>CONCLUSION: Our findings suggest an increase in the activities of mitochondrial respiratory chain in this model of mania. A possible explanation is that these findings occur as a rebound effect trying to compensate for a decrease of ATP deprivation in BD. The present findings suggest that this model may present good face validity and a limitation in construct validity. © 2011 John Wiley & Sons A/S.<p /><p>Language: en</p>",
language="en",
issn="0924-2708",
doi="10.1111/j.1601-5215.2011.00543.x",
url="http://dx.doi.org/10.1111/j.1601-5215.2011.00543.x"
}