@article{ref1,
title="Antiemetic Use in Acetaminophen Poisoning: How Does the Route of N-acetylcysteine Administration Affect Utilization?",
journal="Journal of medical toxicology",
year="2007",
author="Miller, Michelle A. and Navarro, M. and Bird, Steven B. and Donovan, Jenny L.",
volume="3",
number="4",
pages="152-156",
abstract="Introduction: We sought to compare antiemetic use after acetaminophen poisoning in patients treated with oral or intravenous (IV) N-acetylcysteine (NAC). Methods: Our retrospective chart review identified 20 orally treated patients and 17 IV-treated patients. For both groups, we calculated the total number of antiemetic doses given, their associated cost, and also determined parameters that correlated with antiemetic use. Results: IV-treated patients received fewer total antiemetic doses than those receiving oral NAC (1.1 0.2 vs. 2.8 0.7; P 0.04). Antiemetic cost correlated with doses received for both groups; however, because the regression lines differed (P 0.02), antiemetic therapy cost was less in IV-treated patients. In addition, serum acetaminophen concentration correlated with total antiemetic doses in oral NAC patients (P 0.002) but not with IV treatment patients (P 0.78). Conclusions: Intravenous NAC reduced antiemetic utilization, and it costs less than oral therapy. Furthermore, antiemetic use appeared to be determined by a combination of acetaminophen concentration and NAC administration route.<p /> <p>Language: en</p>",
language="en",
issn="1556-9039",
doi="",
url="http://dx.doi.org/"
}