@article{ref1,
title="Histo-pathological findings and their relationship with age, gender and toxin amounts in paraquat intoxication",
journal="Pakistan journal of medical sciences quarterly",
year="2013",
author="Mood, N.E. and Sabzghabaee, A.M. and Ghodousi, A. and Yaraghi, A. and Massoumi, G. and Shemshaki, H.R.",
volume="29",
number="1 Suppl",
pages="403-408",
abstract="OBJECTIVE: Acute paraquat (PQ) poisoning which is taken either to commit suicide or by mistake has become a social concern worldwide. The present study was conducted to determine the histo-pathological findings in deceased PQ poisoning patients and evaluate their relationship with age, gender, amounts of ingested PQ, time from ingestion to admission. <br><br>METHODology: Forty-two patients of PQ poisoning with positive urinary dithionate test were included in the study. Deceased patients underwent autopsy and their histo-pathological findings were examined. <br><br>RESULTS: The mean age of men and women were 29.06 ±10.6 and 16.66 ± 4.6 years respectively. Hepatocellular damage (60%), Tubular nephritis (60%) and pulmonary edema (50%) were the main pathological lesions. Logistic regression analyses identified the following significant predictors for poisoning-related liver lesions: age more than 20 years [odds ratio (OR), 13.75; 95% Confidence Interval (CI), 1.48 - 127.47], and ingested paraquat amounts more than 30 mg /kg (OR, 16; 95% CI, 1.32 - 194.62). There was also a significant correlation between liver lesions and age (Correlation Coefficient, 0.50; P value, 0.024); gender (Correlation Coefficient, 0.57; P value, 0.008); amount of ingested PQ (Correlation Coefficient, 0.55; P value, 0.012). There were no correlations between lung and kidney histopathological lesions with different variables. <br><br>CONCLUSION: Age, amount of ingested PQ, and gender are important parameters which may correlate with histopathological liver lesions in deceased PQ poisoning patients.<p /><p>Language: en</p>",
language="en",
issn="1682-024X",
doi="10.12669/pjms.291(Suppl).3543",
url="http://dx.doi.org/10.12669/pjms.291(Suppl).3543"
}