@article{ref1,
title="Clinical relevance of vilazodone treatment in patients with major depressive disorder: Categorical improvement in symptoms",
journal="Primary care companion to the journal of clinical psychiatry",
year="2014",
author="Culpepper, L. and Mathews, M. and Ghori, R. and Edwards, J.",
volume="16",
number="1",
pages="-",
abstract="OBJECTIVE: To assess clinically relevant symptom improvement in patients with major depressive disorder (MDD) receiving vilazodone by using the Montgomery-Asberg Depression Rating Scale (MADRS), a clinician-rated scale used to measure MDD symptom severity and improvement. <br><br>METHOD: Pooled data from 2 positive, phase 3, 8-week, double-blind, randomized, placebo-controlled trials in patients with MDD were analyzed. Patients received vilazodone 40 mg/d or placebo; post hoc analyses were conducted on study completers. Depression symptom improvement was evaluated by analyzing the proportions of patients who shifted from the baseline MADRS single-item symptom severity category of ≥ 2 (mild to severe symptoms) to an end-of-study category < 2 (minimal to no symptoms) or from ≥ 4 (moderate to severe symptoms) to ≤ 2 (mild to no symptoms). The proportion of patients who shifted from anxious depression to no anxious depression was also analyzed. <br><br>RESULTS: The percentage of patients who completed these studies with severity category shift from baseline ≥ 2 to end of study; 2 was significantly higher for vilazodone versus placebo on all MADRS items (odds ratio [OR] range, 1.4-1.7, P < 05) except reduced appetite (OR = 1.3, P = 232). A significantly greater proportion of vilazodone-treated versus placebo-treated patients shifted from baseline ≥ 4 to end of study ≤ 2 on MADRS items of apparent sadness, reported sadness, inner tension, reduced sleep, and lassitude (OR range, 1.5-2.0, P < 05). Additionally, a significantly greater proportion of vilazodone-treated versus placebo-treated patients shifted from anxious depression at baseline to no anxious depression at end of study (OR = 1.5, P = 031). <br><br>CONCLUSIONS: These results suggest that vilazodone treatment is associated with clinically relevant changes in depression symptoms in patients with MDD. © 2014 Physicians Postgraduate Press, Inc.<p /><p>Language: en</p>",
language="en",
issn="1523-5998",
doi="10.4088/PCC.13m01571",
url="http://dx.doi.org/10.4088/PCC.13m01571"
}