@article{ref1,
title="Prolonged Use of Intravenous Lipid Emulsion in a Severe Tricyclic Antidepressant Overdose",
journal="Journal of medical toxicology",
year="2014",
author="Agarwala, R. and Ahmed, S.Z. and Wiegand, T.J.",
volume="10",
number="2",
pages="210-214",
abstract="INTRODUCTION: Intravenous lipid emulsion (ILE) resuscitation is now frequently being used for severe overdoses due to lipophilic drugs. However, the optimal dose, duration, and safety are still unclear. Case Report: A patient with refractory cardiovascular collapse following an amitriptyline overdose was treated with ILE with initial improvement. Instability recurred after ILE discontinuation and lipid therapy was restarted, but high-dose treatment was complicated by severe lipemia. A low-dose infusion was instead used, and the patient did not experience further toxicity despite amitriptyline levels in the toxic range for 21 days. He survived to discharge without long-term sequelae. <br><br>DISCUSSION: A low-dose infusion of ILE was well tolerated and may have successfully prevented recurrent toxicity in a case of severe tricyclic antidepressant overdose. © 2013 American College of Medical Toxicology.<p /><p>Language: en</p>",
language="en",
issn="1556-9039",
doi="10.1007/s13181-013-0353-4",
url="http://dx.doi.org/10.1007/s13181-013-0353-4"
}