@article{ref1,
title="Colchicine poisoning in pediatric population: About one accidental case and literature review",
journal="Toxicologie analytique et clinique",
year="2016",
author="Kintz, P. and Jamey, C. and Martrille, L. and Raul, J.-s.",
volume="28",
number="1",
pages="79-84",
abstract="Colchicine, an active alkaloid from the plant Colchicum, is used to treat gout and other inflammatory diseases such as familial Mediterranean fever. There is also evidence that colchicine may prove to be a useful adjunct to current therapy in the treatment of pericarditis. The authors present the death of a 4-year-old child, weighing 16kg, who was administered for 2 consecutive days 8mg of colchicine. There was a mistake in the dosage, introducing a confusion between 0.5mg/day and 0.5mg/kg/day. The toxicity of colchicine was increased by the concurrent prescription of azithromycin, a macrolide type antibiotic. After diarrheas and vomiting, the child collapsed with multiple visceral fatal failures. Tested by LC/MS-MS, the concentration of colchicine in peripheral blood was 14.7 ng/mL, with no apparent drug redistribution, as the cardiac blood was tested at 11.8 ng/mL. A high concentration was found in bile that tested positive at 348 ng/mL. Negative hair analysis documented the naïve status of the child. A literature review has confirmed the un-frequent colchicine fatal poisonings in pediatric population in comparison with adults, irrespective of the manner of death, accidental, suicide or homicide. © 2015 Société Française de Toxicologie Analytique.<p /><p>Language: fr</p>",
language="fr",
issn="2352-0078",
doi="10.1016/j.toxac.2015.11.004",
url="http://dx.doi.org/10.1016/j.toxac.2015.11.004"
}