@article{ref1,
title="Advances in NMDA receptors-related antidepressants",
journal="Chinese Pharmacological Bulletin",
year="2018",
author="Guang-Fen, Z. and Jian-Jun, Y.",
volume="34",
number="1",
pages="1-4",
abstract="Recent studies have demonstrated that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can produce rapid and effective antidepressant actions, especially for patients with treatment-resistant depression, bipolar disorder and suicide idea. However, the clinical application of ketamine is limited by its psychotomimetic adverse reactions and potential a-buse. Therefore, development of novel ketamine-like antidepressant agents with fewer side effects is actively investigated cur-rently. The latest researches indicate that the metabolites of ket-amine, the S-ketamine/R-ketamine and the modulators of NMDA receptor subunits can exert safe and effective antidepressant actions. In this article, the research advance in NMDA recep-tors-related antidepressants mentioned above will be reviewed. © 2018 Publication Centre of Anhui Medical University. All rights reserved.<p /><p>Language: zh</p>",
language="zh",
issn="1001-1978",
doi="10.3969/j.issn.1001-1978.2018.01.001",
url="http://dx.doi.org/10.3969/j.issn.1001-1978.2018.01.001"
}