@article{ref1,
title="Midodrine overdose in children: A case report and review of treatment for hypertensive emergencies",
journal="Translational pediatrics",
year="2021",
author="Jan, M. and Brothers, E. and Nakagawa, T.A.",
volume="10",
number="9",
pages="2398-2401",
abstract="Midodrine is an antihypotensive agent used primarily in the adult population for orthostatic hypotension and reflex syncope, postural orthostatic tachycardia syndrome (POTS), and hemodialysis-induced hypotension. Limited information about midodrine ingestion and overdose exists in children with only a single case series reported in the literature. Varying presentations of midodrine ingestion in children have not been shown to be acutely life-threatening in doses up to 50 mg. We present a case of a 12-year-old who intentionally ingested 100 mg of midodrine and presented with a hypertensive emergency and seizure activity. This is the largest reported dose ingested in a child. The patient was observed and treated with a nicardipine infusion in the pediatric intensive care unit (PICU). Prompt identification and treatment of symptoms contributed to a favorable outcome with no neurologic deficits and complete recovery from an intentional ingestion of midodrine. Mechanism, duration of action, and management of midodrine ingestion including treatment for a hypertensive emergency in children are discussed. Commonly used pharmacologic agents to treat hypertension are reviewed. This case report of a significant ingestion of midodrine reviews management of hypertensive emergencies and provides information and guidance to healthcare professionals unfamiliar with this medication and its potentially fatal effects. © 2021 AME Publishing Company. All rights reserved.<p /><p>Language: en</p>",
language="en",
issn="2224-4336",
doi="10.21037/tp-21-153",
url="http://dx.doi.org/10.21037/tp-21-153"
}