@article{ref1,
title="Latent Class Analysis in Depression, including Clinical and Functional Variables: Evidence of a Complex Depressive Subtype in Primary Care in Chile",
journal="Depression research and treatment",
year="2021",
author="Vitriol, V. and Cancino, A. and Serrano, C. and Ballesteros, S. and Ormazábal, M. and Leiva-Bianchi, M. and Salgado, C. and Cáceres, C. and Potthoff, S. and Orellana, F. and Asenjo, A.",
volume="2021",
number="",
pages="-",
abstract="OBJECTIVE. To establish differentiated depressive subtypes using a latent class analysis (LCA), including clinical and functional indicators in a sample of depressed patients consulted in Chilean Primary Health Care. <br><br>METHODS. A LCA was performed on a sample of 297 depressed patients consulted in Chilean PHC. The Mini International Neuropsychiatric Interview, the Hamilton Depression Rating Scale, the Outcome Questionnaire -social role, and interpersonal subscales were as instruments. A regression analysis of the different subtypes with sociodemographic and adverse life experiences was performed. <br><br>RESULTS. In a sample characterized by 87.5% of women, two, three, and four latent class models were obtained. The three-class model likely represents the best clinical implications. In this model, the classes were labeled: &quot;complex depression&quot;(CD) (58% of the sample), &quot;recurrent depression&quot;(RD) (34%), and &quot;single depression episode&quot;(SD) (8%). Members of CD showed a higher probability of history of suicide attempts, interpersonal, and social dysfunction. Psychiatric comorbidities differentiated the RD from SD. According to a multinomial regression model, childhood trauma experiences, recent stressful life experiences, and intimate partner violence events were associated with the CD class (p<0.01). Limitations. The vast majority of participants were females from Chile and the sample studied was not random. So, the results may not necessarily represent outpatient clinics. <br><br>CONCLUSIONS. This study can provide additional evidence that depression, specifically in female gender, could be better understood as a complex heterogeneous disorder when clinical and functional indicators are studied. Furthermore, adverse life experiences starting in childhood could lead to a differentiated complex depressive subtype. © 2021 Verónica Vitriol et al.<p /><p>Language: en</p>",
language="en",
issn="2090-1321",
doi="10.1155/2021/6629403",
url="http://dx.doi.org/10.1155/2021/6629403"
}