@article{ref1,
title="Efficacy of repetitive transcranial magnetic stimulation for alleviating clinical symptoms and suicidal ideation in elderly depressive patients: a randomized controlled trial",
journal="Nan Fang Yi Ke Da Xue Xue Bao",
year="2017",
author="Qin, Bi-Yong and Dai, Li-Lei and Zheng, Yan",
volume="",
number="12",
pages="97-101",
abstract="&lt;p&gt;&lt;b&gt;OBJECTIVE&lt;/b&gt;To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS&lt;/b&gt;A total of 178 elderly depressive patients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment. The treatment response was defined as a 25% reduction in HAMD scores from baseline, and an early improvement as 20% reduction in HAMD scores after 2 weeks of treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS&lt;/b&gt;The two groups of patients were comparable for baseline socio-demographic characteristics and baseline SIOSS and HAMD scores (P&gt;0.05). After 2 and 4 weeks of treatment, both SIOSS and HAMD scores were improved in the two groups, but the patients in rTMS group showed a significantly faster score reduction. A significantly higher rate of early improvement at 2 weeks (52.5% vs 28.6%; &chi;=10.569, P&lt;0.01) and a higher response rate at 4 weeks (77.5% vs 53.1%; &chi;=15.470, P&lt;0.05) were observed in rTMS group.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS&lt;/b&gt;rTMS combined with medications can effectively improve sleep quality, cognitive impairment and somatization symptom and reduce suicidal ideation in elderly patients with depression.&lt;/p&gt;<p /><p>Language: zh</p>",
language="zh",
issn="1673-4254",
doi="",
url="http://dx.doi.org/"
}