@article{ref1,
title="All-trans retinoic acid enhances bystander effect of suicide-gene therapy against androgen-unresponsive prostate cancer",
journal="Zhonghua Nan Ke Xue",
year="2008",
author="Chen, Wei-Guo and Yan, Chun-Yin and Hou, Jian-Quan and Wen, Duan-Gai and Pu, Jin-Xian and Wang, Heng-Bing",
volume="",
number="12",
pages="122-125",
abstract="&lt;p&gt;&lt;b&gt;OBJECTIVE&lt;/b&gt;To investigate the enhancing effect of all-trans retinoic acid (ATRA) on the bystander effect of the herpes simplex virus thymidine kinase(HSV-TK)/ganciclovir (GCV) against androgen unresponsive prostate cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS&lt;/b&gt;The bystander effect of the HSV-TK/GCV system was measured by methyl thiazolyl tetrazolium (MTT) assay on PC-3 cells before and after ATRA treatment. The growth and the histopathology of transplant tumors were observed in 4 groups of nude mice with prostate cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS&lt;/b&gt;ATRA augmented significantly the bystander effect of the HSV-TK/GCV system by reducing TK positive PC-3 cells from 50% to 30% (P &lt; 0.05). HSV-TK showed an inhibiting effect, while ATRA with the HSV-TK/GCV system produced significant effect on prostate cancer 1 week earlier than the former (P &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION&lt;/b&gt;ATRA can argument the in vivo and in vitro bystander effect of the HSV-TK/GCV system in the treatment of androgen unresponsive prostate cancer.&lt;/p&gt;<p /><p>Language: zh</p>",
language="zh",
issn="1009-3591",
doi="",
url="http://dx.doi.org/"
}