@article{ref1,
title="Clinical comparison on the effects of escitalopram and amitriptyline in treating depression patients with suicide-related symptoms",
journal="Chinese Journal of Behavioral Medicine and Brain Science",
year="2014",
author="Chen, Gengyi and Gao, Zhensong and Chen, Zhengxiong",
volume="",
number="12",
pages="338-340",
abstract="OBJECTIVE To explore the effects and safety of escitalopram on suicide-related symptoms for depression patients controlled with amitriptyline.<br><br>METHODS Depression patients with suicide-related symptoms were randomly grouped.The study group(n=35) were treated with escitalopram 10 mg/d to 20 mg/d and the control group(n=33) were done with amitriptyline 75 mg to 250 mg daily.Both groups with psychotherapy were carried out for 8 weeks' observation.The Hamilton Depression Rating Scale (HAMD-17) and Clinical Global Impression-severity of illness (CGI-SI) were tested and suicide-related examined before and after 1,2,4,6 and 8 weeks'treatment.The Treatment Emergent Symptom Scale (TESS) was checked at 4th week to evaluate safety.<br><br>RESULTS In the study group,the incidence of wishing to die (97.1％),suicidal attempts (91.4％),suicidal ideations (88.6％),suicidal plans (80.0％),hopelessness (71.4％) and suicidal behavior (54.3％) was similar to the control group(97.0％,97.0％,90.9％,87.9％,72.7％ and 54.5％,respectively,x2 =0.00-0.94,P＞0.05).The incidence of suicide-related symptoms showed significantly lower after treatment than before (P＜0.01).At 1st week treatment,the incidences of hopelessness (37.1％),suicidal plans (45.7％) and suicidal ideations (48.6％)showed significantly lower in the study group than those in the control group(63.6％,72.7％ and 75.8％,respectively,x2 =4.77,5.12,5.32,P＜ 0.05).The study group showed significantly lower side-effects (11.4％) at 4th weeks' treatment than the control group(62.9％,x2 =21.95,P＜0.01).<br><br>CONCLUSION The effects of escitalopram on suicide-related symptoms for depression patients is similar to amitriptyline but with faster effect and higher safety.<p /><p>Language: zh</p>",
language="zh",
issn="1674-6554",
doi="10.3760/cma.j.issn.1674-6554.2014.04.015",
url="http://dx.doi.org/10.3760/cma.j.issn.1674-6554.2014.04.015"
}