@article{ref1,
title="Effect of adenovirus-mediated CD/TK double suicide gene system on colorectal cancer growth and cytokines in the tumor microenvironment in mice",
journal="Nan Fang Yi Ke Da Xue Xue Bao",
year="2010",
author="Yao, Xiao-jun and Huang, Zong-hai and Li, Qiang and Wang, Zhao-yang",
volume="",
number="12",
pages="260-262",
abstract="&lt;p&gt;&lt;b&gt;OBJECTIVE&lt;/b&gt;To evaluate the effect of adenovirus-mediated CD/TK double suicide gene system on tumor growth and cytokine levels in the tumor microenvironment in mice bearing transplanted colorectal cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS&lt;/b&gt;CT26 cells were implanted subcutaneously into 30 Balb/c mice, which were subsequently randomized into the control (n=15) and experimental group (n=15). After the tumor formation, CD/TK double suicide gene system was administered for tumor treatment, and the changes in the tumor volume, tumor inhibition rate, and levels of cytokines in the tumor microenvironment were investigated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS&lt;/b&gt;CD/TK double suicide gene system resulted in a significant inhibition of the tumor growth and significantly increased levels of such cytokines as IL-2, IL-10, TNFalpha and IFNgamma in the tumor microenvironment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION&lt;/b&gt;CD/TK double suicide gene system produces significant tumor inhibition effect and causes obvious cytokine changes in the tumor microenvironment in mice bearing transplanted colorectal cancer.&lt;/p&gt;<p /><p>Language: zh</p>",
language="zh",
issn="1673-4254",
doi="",
url="http://dx.doi.org/"
}