@article{ref1,
title="Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Bipolar I Disorder",
journal="Journal of Korean Neuropsychiatric Association",
year="2004",
author="Pae, Chi-Un and Kim, Tae-Suk and Jang, Woo-Young and Kim, Jung-Jin and Lee, Chang-Uk and Lee, Soo-Jung and Jun, Tae-Youn and Lee, Chul and Paik, In-Ho",
volume="",
number="",
pages="524-528",
abstract="OBJECTIVES: Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD. <br><br>METHODS: Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. <br><br>RESULTS: Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. <br><br>CONCLUSION: Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.<p /><p>Language: ko</p>",
language="ko",
issn="1015-4817",
doi="",
url="http://dx.doi.org/"
}