@article{ref1,
title="Tumor-specific promoters and their application in cancer gene targeted therapy",
journal="Journal of International Oncology",
year="2008",
author="Chen, Xiaopeng and Hu, Lianghe and Tong, Chaogang",
volume="",
number="12",
pages="566-569",
abstract="Tumor-specific promoters can induce high-efficiency and specific expression of exogenous genes in tumor cells. At present, commonly used promoters include alpha-fetoprotein promoter, carcinoembryonic antigen promoter,prostate specific antigen promoter,human telomerase reverse transcriptase promoter and multidrug resistance gene promoter and etc. Dual promoters, enhancer, regulatory element and other physical or chem-ical factors could be used to reconstruct or modify promoters to increase the expression and location of exogenous genes in tumor cells. Tumor-specific promoters play an important role in cancer gene targeted therapy by cou-pling with suicide gene, anti- oncogene, antiseuse nucleic acid, apoptosis gene and RNA interference.<p /><p>Language: zh</p>",
language="zh",
issn="1673-422X",
doi="",
url="http://dx.doi.org/"
}