@article{ref1,
title="Levetiracetam induces severe psychiatric symptoms in people with epilepsy",
journal="Seizure",
year="2024",
author="Wang, Xuefeng and Gu, Yixue and Chen, Yuanyuan and Chen, Hongnian and Tao, Kaiyan",
volume="116",
number="",
pages="147-150",
abstract="BACKGROUND: Drug-induced psychiatric symptoms are an important cause of treatment failure. Worldwide, levetiracetam has been widely used to treat epilepsy; however, associated psychobehavioral abnormalities have been observed. This study aimed to characterize levetiracetam-induced severe psychiatric symptoms and to propose preventive and therapeutic measures. <br><br>METHODS: In this retrospective cluster sampling study, psychiatric symptoms of patients who had taken levetiracetam for at least 1 month were analyzed. <br><br>RESULTS: 111(7.8%) of the 1,412 included patients exhibited severe psychiatric symptoms. Hallucinations, delusions, aggressive behavior, and agitation were the most common manifestations. Some patients also showed suicidal and self-harm behaviors. These symptoms were mainly controlled by reducing the dose of levetiracetam, stopping the drug, or adding antipsychotic drugs to the treatment regimen. <br><br>CONCLUSION: The severe psychiatric symptoms caused by levetiracetam require special attention.<p /> <p>Language: en</p>",
language="en",
issn="1059-1311",
doi="10.1016/j.seizure.2022.12.002",
url="http://dx.doi.org/10.1016/j.seizure.2022.12.002"
}