@article{ref1,
title="Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study",
journal="Environment international",
year="2022",
author="Andersen, Zorana J. and Zhang, Jiawei and Jørgensen, Jeanette T. and Samoli, Evangelia and Liu, Shuo and Chen, Jie and Strak, Maciej and Wolf, Kathrin and Weinmayr, Gudrun and Rodopolou, Sophia and Remfry, Elizabeth and de Hoogh, Kees and Bellander, Tom and Brandt, Jørgen and Concin, Hans and Zitt, Emanuel and Fecht, Daniela and Forastiere, Francesco and Gulliver, John and Hoffmann, Barbara and Hvidtfeldt, Ulla A. and Monique Verschuren, W. M. and Jöckel, Karl-Heinz and So, Rina and Cole-Hunter, Tom and Mehta, Amar J. and Mortensen, Laust H. and Ketzel, Matthias and Lager, Anton and Leander, Karin and Ljungman, Petter and Severi, Gianluca and Boutron-Ruault, Marie-Christine and Magnusson, Patrik K. E. and Nagel, Gabriele and Pershagen, Göran and Peters, Annette and Rizzuto, Debora and van der Schouw, Yvonne T. and Schramm, Sara and Stafoggia, Massimo and Katsouyanni, Klea and Brunekreef, Bert and Hoek, Gerard and Lim, Youn-Hee",
volume="170",
number="",
pages="107581-107581",
abstract="Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM(2.5)), nitrogen dioxide (NO(2)), black carbon (BC), ozone (O(3)), and 8 PM(2.5) components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO(2) (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m(3)), PM(2.5) (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m(3)), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10(-5)/m) with psychiatric disorders mortality, as well as with suicide (NO(2): HR = 1.13 [95 % CI: 0.92, 1.38]; PM(2.5): HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O(3) and 8 PM(2.5) components with any of the three mortality outcomes. Long-term exposure to NO(2), PM(2.5), and BC may lead to premature mortality from psychiatric disorders and suicide.<p /><p>Language: en</p>",
language="en",
issn="0160-4120",
doi="10.1016/j.envint.2022.107581",
url="http://dx.doi.org/10.1016/j.envint.2022.107581"
}