@article{ref1,
title="Longitudinal course and predictors of depressive symptoms in atopic dermatitis",
journal="Journal of the American Academy of Dermatology",
year="2022",
author="Gabriel, Sylvie and Chavda, Rajeev and Yousaf, Muhammad and Lei, Donald and Chatrath, Sheena and Silverberg, Jonathan I.",
volume="87",
number="3",
pages="582-591",
abstract="BACKGROUND: Atopic dermatitis (AD) is associated with eczematous lesions, pruritus, pain, and sleep disturbance, which may negatively impact mental health over time. <br><br>OBJECTIVE: To determine the predictors and longitudinal course of depressive symptoms in adults with AD. <br><br>METHODS: A prospective, dermatology practice-based study was performed (N = 695). AD signs, symptoms, and severity and patient health questionnaire-9 (PHQ-9) were assessed. <br><br>RESULTS: At baseline, of the 695 participants, 454 (65.32%) had minimal, 139 (20.00%) had mild, 57 (8.20%) had moderate, 27 (3.88%) had moderately severe, and 8 (2.59%) had severe depression. Most had fluctuating levels of depressive symptoms. Feeling bad, thoughts of self-harm, difficulty concentrating, and slow movement were most persistent. Predictors of persistent depression included older age, non-White race, male sex, public or no insurance, more severe itch, skin pain, facial erythema, nipple eczema, sleep disturbance, and presence of pityriasis alba. LIMITATIONS: Single center study. <br><br>CONCLUSION: Depressive symptoms are closely related to and fluctuate with AD severity over time. Improved control of AD signs and symptoms, particularly itch, may secondarily improve mental health.<p /><p>Language: en</p>",
language="en",
issn="0190-9622",
doi="10.1016/j.jaad.2022.04.061",
url="http://dx.doi.org/10.1016/j.jaad.2022.04.061"
}