@article{ref1,
title="Sleep disturbances and incident risk of major depressive disorder in a population-based cohort",
journal="Psychiatry research",
year="2024",
author="Solelhac, Geoffroy and Imler, Théo and Strippoli, Marie-Pierre F. and Marchi, Nicola Andrea and Berger, Mathieu and Haba-Rubio, José and Raffray, Tifenn and Bayon, Virginie and Lombardi, Anne Sophie and Ranjbar, Setareh and Siclari, Francesca and Vollenweider, Peter and Marques-Vidal, Pedro and Geoffroy, Pierre-Alexis and Leger, Damien and Stephan, Aurélie and Preisig, Martin and Heinzer, Raphael",
volume="338",
number="",
pages="e115934-e115934",
abstract="Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD. Survival Cox models were used to analyze associations between sleep features and MDD incidence. A higher Epworth Sleepiness Scale and presence of insomnia symptoms were significantly associated with a higher incidence of MDD (hazard ratio [HR] [95 % confidence interval (CI)]: 1.062 [1.022-1.103], p = 0.002 and 1.437 [1.064-1.940], p = 0.018, respectively). Higher density of rapid eye movements in rapid eye movement (REM) sleep was associated with a higher incidence of MDD in men (HR 1.270 [95 % CI 1.064-1.516], p = 0.008). In women, higher delta power spectral density was associated with a lower MDD incidence (HR 0.674 [95 % CI 0.463-0.981], p = 0.039). This study confirmed the associations between subjective and objective sleep features and the incidence of MDD in a large community dwelling cohort.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2024.115934",
url="http://dx.doi.org/10.1016/j.psychres.2024.115934"
}