@article{ref1,
title="Case Report: Buprenorphine-A Treatment for Psychological Pain and Suicidal Ideation?",
journal="American journal on addictions",
year="2021",
author="Benhamou, Ori-Michael and Lynch, Sean and Klepacz, Lidia",
volume="30",
number="1",
pages="80-82",
abstract="BACKGROUND AND OBJECTIVES: Buprenorphine is commonly used to manage opioid use disorder; however, the literature describes its potential role in treating treatment-resistant depression. METHODS: We present a patient with bipolar disorder and opioid use disorder, who presented status post-suicide attempt. RESULTS: After initiating buprenorphine-naloxone, the patient reported rapid improvement in depressive symptoms, pain, and suicidal ideation. DISCUSSION AND CONCLUSIONS: This case demonstrates buprenorphine's antisuicidal and mood-stabilizing capabilities, potentially via antagonizing κ-opioid receptors as well as reinstating the balance between reward and antireward circuitry. SCIENTIFIC SIGNIFICANCE: This case highlights buprenorphine-naloxone as a treatment for both treatment-resistant depression and opioid use disorder, as well as buprenorphine's rapid antidepressant, analgesic, and antisuicidal effects. (Am J Addict 2021;30:80-82).<p /><p>Language: en</p>",
language="en",
issn="1055-0496",
doi="10.1111/ajad.13063",
url="http://dx.doi.org/10.1111/ajad.13063"
}