@article{ref1,
title="Psychiatric comorbidity in childhood onset immune-mediated diseases-A systematic review and meta-analysis",
journal="Acta paediatrica",
year="2022",
author="Jansson, Sabine and Malham, Mikkel and Wewer, Vibeke and Rask, Charlotte Ulrikka",
volume="111",
number="3",
pages="490-499",
abstract="AIM: To estimate psychiatric comorbidity in childhood onset immune-mediated inflammatory diseases (IMID). METHODS: The PRISMA guidelines were followed, and the protocol was registered at Prospero (ID: CRD42021233890). Literature was searched in PubMed, PsycINFO and Embase. Original papers on prevalence rates of diagnosed psychiatric disorders and/or suicide in paediatric onset inflammatory bowel disease (pIBD), rheumatic diseases (RD) and autoimmune liver diseases were selected. Pooled prevalence rates of psychiatric disorders (grouped according to ICD-10 criteria) within the various IMID were calculated using random-effects meta-analysis. Risk of bias was evaluated by the Newcastle-Ottawa scale. RESULTS: Twenty-three studies were included; 13 describing psychiatric disorders in pIBD and 10 in RD. Anxiety and mood disorders were mostly investigated with pooled prevalence rates in pIBD of 6% (95% confidence interval (CI): 4%-9%) and 4% (95%CI: 2%-8%), respectively, in register-based studies, and 33% (95%CI: 25%-41%) and 18% (95%CI: 12%-26%), respectively, in studies using psychiatric assessment. In RD, rates were 13% (95%CI: 12%-15%) for anxiety disorders and 20% (95%CI: 15%-26%) for mood disorders based on psychiatric assessment. CONCLUSION: Anxiety and depression are commonly reported in childhood onset IMID. Physicians should be attentive to mental health problems in these patients as they seem overlooked.<p /><p>Language: en</p>",
language="en",
issn="0803-5253",
doi="10.1111/apa.16246",
url="http://dx.doi.org/10.1111/apa.16246"
}