@article{ref1,
title="Mental health among patients with non-Hodgkin lymphoma: A Danish nationwide study of psychotropic drug use in 8750 patients and 43 750 matched comparators",
journal="American journal of hematology",
year="2022",
author="Øvlisen, Andreas Kiesbye and Jakobsen, Lasse Hjort and Kragholm, Kristian Hay and Nielsen, René Ernst and de Nully Brown, Peter and Dahl-Sørensen, Rasmus Bo and Frederiksen, Henrik and Mannering, Nikolaj and Josefsson, Pär Lars and Ludvigsen Al-Mashhadi, Ahmed and Jørgensen, Judit Mészáros and Dessau-Arp, Andriette and Clausen, Michael Roost and Pedersen, Robert Schou and Torp-Pedersen, Christian and Severinsen, Marianne Tang and El-Galaly, Tarec Christoffer",
volume="97",
number="6",
pages="749-761",
abstract="Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. Non-Hodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDs-antidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide population-based registries to investigate the cumulative risk of PD use in NHL patients compared to a sex- and age-matched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional self-harm or completed suicide were explored. In total, 8750 NHL patients and 43 750 matched comparators were included (median age 68; male:female ratio 1.6). Median follow-up was 7.1 years. Two-year cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p < .01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5 years into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher two-year risk of suicide/intentional self-harm (0.3%) as compared to the matched comparators (0.2%, p = .01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard follow-up of NHL patients.<p /><p>Language: en</p>",
language="en",
issn="0361-8609",
doi="10.1002/ajh.26538",
url="http://dx.doi.org/10.1002/ajh.26538"
}