@article{ref1,
title="Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains",
journal="European journal of medicinal chemistry",
year="1992",
author="Elloumi, N. and Moreau, B. and Aguiar, L. and Jaziri, N. and Sauvage, M. and Hulen, C. and Capmau, M.",
volume="27",
number="2",
pages="149-154",
abstract="The synthesis of 5′-amino-5′-deoxy guanosine was improved in order to use it for elaboration of liposolubles GDP-mannose analogues. GDP-mannose is the substrate of GDP-mannose dehydrogenase, a key enzyme in the alginates biosynthetic pathway of Pseudomonas aeruginosa mucoid strains. Guanosine, 5′-amino-5′-deoxy-guanosine, 5′-(3-hydroxypropyl)-amino-5′-deoxy-guanosine and 2 GDP mannose analogues were tested on the GDP mannose dehydrogenase activity. The more potent inhibitor was the GDP-mannose analogue where mannose is substituted by a 6-ethynyl derivative, linked to an N2-acetyl-2′,3′-O-isopropylidene guanosine by a sulfonyl amino carbonyl arm. As a hypothesis, this compound could be a suicide or irreversible inhibitor for the enzyme. © 1992.<p /><p>Language: en</p>",
language="en",
issn="0223-5234",
doi="10.1016/0223-5234(92)90103-8",
url="http://dx.doi.org/10.1016/0223-5234(92)90103-8"
}