@article{ref1,
title="2-deoxy-D-glucose suppresses food intake through activation of hypothalamic histamine in rats",
journal="American journal of physiology",
year="1994",
author="Sakata, T. and Tamari, Y. and Kang, M. and Yoshimatsu, H.",
volume="267",
number="2 Pt 2",
pages="R616-618",
abstract="The aim of this experiment was to demonstrate whether brain histamine contributes to delayed suppression of food intake after administration of 2-deoxy-D-glucose (2-DG). Food intake decreased significantly for 48 h after infusion of 2-DG into the rat third cerebroventricle. This delayed decrease in food intake was abolished by depletion of neuronal histamine by intraperitoneal pretreatment with alpha-fluoromethylhistidine (160 mumol/rat), a suicide inhibitor of a histamine-synthesizing enzyme. Intracerebroventricular infusion of 24 mumol 2-DG accelerated turnover rate of hypothalamic histamine. These results indicate that the delayed feeding suppression by 2-DG is modulated through histaminergic neurons in the hypothalamus. This histaminergic response may be related, at least in part, to homeostatic control of energy metabolism in the brain.<p /><p>Language: en</p>",
language="en",
issn="0002-9513",
doi="10.1152/ajpregu.1994.267.2.R616",
url="http://dx.doi.org/10.1152/ajpregu.1994.267.2.R616"
}