@article{ref1,
title="Estimated glucose requirement following massive insulin overdose in a patient with type 1 diabetes",
journal="Diabetic medicine",
year="1994",
author="Fasching, P. and Roden, M. and Stühlinger, H. G. and Kurzemann, S. and Zeiner, A. and Waldhäusl, W. and Laggner, A. N.",
volume="11",
number="3",
pages="323-325",
abstract="A well-documented case of a 35-year-old male Type 1 diabetic patient who was admitted as an emergency after having injected 1500 international units (IU) of insulin (750 IU regular insulin,750 IU NPH-insulin) subcutaneously as a suicidal attempt is reported. Computing disappearance rates of glucose from its infused amounts necessary to maintain euglycaemia during 65 h after the insulin injection in analogy to experimental hyperinsulinaemic euglycaemic clamp examinations, a glucose consumption of 55.6 mumol kg-1 min-1 was found at peak serum insulin concentrations of about 14,400 pmol l-1. The insulin-induced glucose dynamics resemble closely those seen in healthy persons and Type 1 diabetic subjects during a 10 mU kg-1 min-1 euglycaemic clamp. This information may be useful in the handling of similar cases of insulin intoxication.<p /><p>Language: en</p>",
language="en",
issn="0742-3071",
doi="10.1111/j.1464-5491.1994.tb00279.x",
url="http://dx.doi.org/10.1111/j.1464-5491.1994.tb00279.x"
}