@article{ref1,
title="Massive isotretinoin intoxication",
journal="Clinical and experimental dermatology",
year="1995",
author="Aubin, S. and Lorette, G. and Müller, C. and Vaillant, L.",
volume="20",
number="4",
pages="348-350",
abstract="We report a case of acute intoxication due to a massive overdose of isotretinoin. A 29-year-old male patient ingested 900 mg of isotretinoin corresponding to 12.5 mg (kg/day) or 30 times the prescribed dosage and 1 day later the patient experienced mild headache. Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion. The side-effects were mild and represented only exacerbations of some common isotretinoin side-effects. To date, three other cases of isotretinoin overdosage have been reported. There was a low toxicity of isotretinoin overdose.<p /><p>Language: en</p>",
language="en",
issn="0307-6938",
doi="10.1111/j.1365-2230.1995.tb01341.x",
url="http://dx.doi.org/10.1111/j.1365-2230.1995.tb01341.x"
}