@article{ref1,
title="Gas chromatographic determination of cresols in the biological fluids of a non-fatal case of cresol intoxication",
journal="Forensic science international",
year="1990",
author="Yashiki, M. and Kojima, T. and Miyazaki, T. and Chikasue, F. and Ohtani, M.",
volume="47",
number="1",
pages="21-29",
abstract="A simple and rapid method for analysis of free and conjugated cresols in biological fluids was developed. Prior to and following freeing of the conjugated cresols by acid hydrolysis in a sealed ampoule, free cresols were extracted by Extrelut column extraction, determined by gas chromatography, and confirmed by gas chromatography-mass spectrometry. In a non-fatal case of cresol intoxication a 46-year-old male had ingested about 100 ml of a saponated cresol soap solution. The concentrations of xylenol (2,4- and/or 2,5-dimethylphenol) and p- and m-cresol in the serum sample collected on admission were 15.8 micrograms/g, 43.3 micrograms/g and 73.8 micrograms/g, respectively. The total cresol concentration of 117 micrograms/g in the serum is within the range of fatal concentrations, and it is suspected therefore that the patient's recovery was due to adequate therapy alone.<p /><p>Language: en</p>",
language="en",
issn="0379-0738",
doi="10.1016/0379-0738(90)90282-4",
url="http://dx.doi.org/10.1016/0379-0738(90)90282-4"
}