@article{ref1,
title="Synthesis and biochemical evaluation of the novel steroid androsta-4,6,8(9)-triene-3,17-dione",
journal="Journal of Enzyme Inhibition",
year="1990",
author="Panzeri, A. and Ornati, G. and di Salle, E. and Lombardi, P.",
volume="4",
number="2",
pages="121-129",
abstract="According to a proposed aromatisation mechanism by which estrogens are biosynthesized from androgens, the novel steroid androsta-4,6,8(9)-triene-3,17-dione (FCE 24918) should behave as a suicide substrate for aromatase. The synthesis of this triene steroid has been accomplished starting from androsta-4,7-diene-3,17-dione (4) by the acid-catalysed cleavage of the corresponding 7,8 alpha-epoxide, 5, and it was obtained together with androsta-4,6,8(14)-triene-3,17-dione (FCE 24917) as a side product. The time-dependent inactivation of placental aromatase by the two isomers was studied comparatively and showed that the 4,6,8(9)-triene moiety acts as a latent alkylating group.<p /><p>Language: en</p>",
language="en",
issn="8755-5093",
doi="10.3109/14756369009040733",
url="http://dx.doi.org/10.3109/14756369009040733"
}