@article{ref1,
title="3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin",
journal="Canadian journal of neurological sciences",
year="1991",
author="Ludolph, A. C. and He, F. and Spencer, P. S. and Hammerstad, J. and Sabri, M.",
volume="18",
number="4",
pages="492-498",
abstract="3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.<p /><p>Language: en</p>",
language="en",
issn="0317-1671",
doi="10.1017/s0317167100032212",
url="http://dx.doi.org/10.1017/s0317167100032212"
}