@article{ref1,
title="Brain [3H]cAMP binding sites are unaltered in depressed suicides, but decreased by antidepressants",
journal="Brain research",
year="1997",
author="Lowther, S. and Katona, C. L. and Crompton, M. R. and Horton, R. W.",
volume="758",
number="1-2",
pages="223-228",
abstract="Saturation binding of [3H]cAMP to the regulatory subunit of cAMP-dependent protein kinase (PKA) was measured in the soluble fraction of brain samples, obtained at post-mortem, from suicides with a firm retrospective diagnosis of depression and individually matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. In antidepressant-free suicides, we found no significant differences in the number or affinity of [3H]cAMP binding sites in the five regions studied. In antidepressant-treated suicides however, Bmax values were lower in all regions, reaching statistical significance in parietal cortex and amygdala. Kd values for antidepressant-treated suicides were significantly higher in parietal cortex, temporal cortex and amygdala. These results suggest the regulatory subunit of PKA is unaltered in depression, but is influenced by antidepressant drugs.<p /><p>Language: en</p>",
language="en",
issn="0006-8993",
doi="10.1016/s0006-8993(97)00232-1",
url="http://dx.doi.org/10.1016/s0006-8993(97)00232-1"
}