@article{ref1,
title="Acute renal failure after massive ingestion of gliclazide in a suicide attempt",
journal="Renal failure",
year="1998",
author="Barracca, A. and Ledda, O. and Michittu, B. and Pili, G. F. and Manca, O. and Pani, A. and Altieri, P.",
volume="20",
number="3",
pages="533-537",
abstract="Gliclazide, a sulfonlyurea class molecule, is used to control glycaemic levels in non-insulin-dependent diabetes mellitus. Acute and chronic toxicity studies, conducted in various animal species, have demonstrated a very low toxicity. We report a patient who developed acute renal failure due to acute tubular necrosis following a massive ingestion of gliclazide in an suicide attempt. The patient ingested 28 grams of gliclazide; the normal dose of gliclazide is 80 mg one or twice a day. At admission the patient was hypoglycaemia and in a few days became oliguric with an increase in the serum creatinine concentration, but with a normal blood urea nitrogen level. He underwent dialysis and ten days after ingestion of gliclazide, his renal function improved rapidly.<p /><p>Language: en</p>",
language="en",
issn="0886-022X",
doi="10.3109/08860229809045142",
url="http://dx.doi.org/10.3109/08860229809045142"
}