@article{ref1,
title="Psychosis during chronic levodopa therapy triggered by the new antidepressive drug mirtazapine",
journal="Pharmacopsychiatry",
year="1997",
author="Normann, C. and Hesslinger, B. and Frauenknecht, S. and Berger, M. and Walden, J.",
volume="30",
number="6",
pages="263-265",
abstract="We report the case of a patient developing psychosis after the addition of mirtazapine, a novel antidepressant enhancing serotonergic neurotransmission, to a chronic levodopa regimen. There was complete and rapid recovery upon low-dose clozapine treatment. To our knowledge, this is the first published case of a mirtazapine-levodopa interaction and the second case report of a psychosis induced by a serotonergic antidepressant in a patient with Parkinson's disease (PD). This phenomenon might be due to a postsynaptic serotonin receptor supersensitization caused by low central serotonin levels in treated PD.<p /><p>Language: en</p>",
language="en",
issn="0176-3679",
doi="10.1055/s-2007-979504",
url="http://dx.doi.org/10.1055/s-2007-979504"
}