@article{ref1,
title="Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder",
journal="Neuroreport",
year="1999",
author="Caberlotto, L. and Hurd, Y. L.",
volume="10",
number="8",
pages="1747-1750",
abstract="In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.<p /><p>Language: en</p>",
language="en",
issn="0959-4965",
doi="10.1097/00001756-199906030-00022",
url="http://dx.doi.org/10.1097/00001756-199906030-00022"
}