@article{ref1,
title="Non-fatal clozapine (LEPONEX) intoxication with toxicokinetic evaluation",
journal="Veterinary and human toxicology",
year="1999",
author="Bédry, R. and Deschamps, L. and Pehourcq, F. and Moore, N. and Pillet, O. and Favarel-Garrigues, J. C.",
volume="41",
number="1",
pages="20-22",
abstract="A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated.<p /><p>Language: en</p>",
language="en",
issn="0145-6296",
doi="",
url="http://dx.doi.org/"
}