@article{ref1,
title="The structure-activity relationships of a series of suicide inhibitors of phospholipase A2",
journal="Bioorganic and medicinal chemistry letters",
year="1998",
author="Yu, L. and Ternansky, R. J. and Victoria, E. J. and Chang, J. and Coutts, S. M.",
volume="8",
number="16",
pages="2129-2132",
abstract="A series of mechanism-based inhibitors of phospholipase A2 (SIBLINKS) were synthesized. These new SIBLINKS are phospholipid analogues that contain a para-substituted phenyl 3,3-dimethylglutaryl group in the place of the sn-2 acyl chain. The effect of the phenyl leaving group on inhibitory activity was studied by varying the electron-withdrawing ability of the para-substituted group. A strong correlation was observed between the leaving group potential of the suicide inhibitor and the inhibitory activity of the derivative toward cobra venom phospholipase A2.<p /><p>Language: en</p>",
language="en",
issn="0960-894X",
doi="10.1016/s0960-894x(98)00378-3",
url="http://dx.doi.org/10.1016/s0960-894x(98)00378-3"
}