@article{ref1,
title="A suicide-substrate mechanism for hydrolysis of beta-lactams by an anti-idiotypic catalytic antibody",
journal="FEBS letters",
year="2001",
author="Lefèvre, S. and Debat, H. and Thomas, D. and Friboulet, A. and Avalle, B.",
volume="489",
number="1",
pages="25-28",
abstract="The catalytic mechanism of an anti-idiotypic antibody, 9G4H9, displaying a beta-lactamase activity was investigated. Kinetics experiments suggest that some penicillinic derivatives behave both as substrates and inactivators. Biochemical and immunological experiments strongly indicate that ampicillin may be regarded as a suicide substrate for hydrolysis by 9G4H9. The anti-idiotypic network appears as a way to create enzyme mimics with modified catalytic activities.<p /><p>Language: en</p>",
language="en",
issn="0014-5793",
doi="10.1016/s0014-5793(01)02075-0",
url="http://dx.doi.org/10.1016/s0014-5793(01)02075-0"
}