@article{ref1,
title="Neurokinin-1 receptors are decreased in major depressive disorder",
journal="Neuroreport",
year="2002",
author="Stockmeier, Craig A. and Shi, Xiaochun and Konick, Lisa and Overholser, James C. and Jurjus, George and Meltzer, Herbert Y. and Friedman, Lee and Blier, Pierre and Rajkowska, Grazyna",
volume="13",
number="9",
pages="1223-1227",
abstract="Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.<p /><p>Language: en</p>",
language="en",
issn="0959-4965",
doi="10.1097/00001756-200207020-00031",
url="http://dx.doi.org/10.1097/00001756-200207020-00031"
}