@article{ref1,
title="High-dose exposure to valsartan with suicidal intention",
journal="International journal of clinical pharmacology and therapeutics",
year="2004",
author="Kumbasar, B. and Atlibatur Akbas, F. and Serez, K. and Ger, E. and Uzunoglu, S. and Ergen, K. and Ayer, M.",
volume="42",
number="6",
pages="328-329",
abstract="Valsartan is a strong angiotensin receptor inhibitor specific for the angiotensin I receptor, which has been proven safe and well-tolerated in clinical trials. We were able to confirm its safety and tolerability in a case of high-dose exposure to valsartan with suicidal intention. A 25-year-old, fully conscious, female patient was brought to our hospital by relatives on July 24, 2001, at 9:15 p.m. following intake of a high dose of valsartan. It was established that she had taken 28 Diovan 80 mg tablets (2.24 g) 5 hours before admission to the hospital. Her clinical condition at the time of admission was good and did not deteriorate after admission. During the follow-up, her blood pressure never fell below 90/60 mmHg. The only complaint she had were painful muscle cramps which, with only supportive therapy, disappeared spontaneously over 2 days, and her blood pressure also returned to normal during this period. This report demonstrates the effect/side effect profile of valsartan when taken at a high dose, not achievable in a clinical trial.<p /><p>Language: en</p>",
language="en",
issn="0946-1965",
doi="10.5414/cpp42328",
url="http://dx.doi.org/10.5414/cpp42328"
}