@article{ref1,
title="Serotonin dysfunction and suicide attempts in major depressives: an auditory event-related potential study",
journal="Neuropsychobiology",
year="2005",
author="Chen, Tai-Jui and Yu, Younger W.-Y. and Chen, Ming-Chao and Wang, Shing-Yaw and Tsai, Shih-Jen and Lee, Tien-Wen",
volume="52",
number="1",
pages="28-36",
abstract="BACKGROUND: Serotonergic dysfunction is believed to be involved in suicide attempts. The loudness-dependent auditory evoked potential (LDAEP) is one of the validated indicators of the activity of the central serotonin system in humans. OBJECTIVES: This study was designed to investigate possible differences in the LDAEP and P300 between those depressed patients who attempted suicide and those who did not. METHODS: The LDAEP and P300 levels were recorded for 66 depressive patients (among which 16 had attempted suicide). RESULTS: Those who had attempted suicide showed a sharper slope of the LDAEP and increased frontal P300 amplitude. A high correlation between the LDAEP and P300, and a gender difference were also noted. CONCLUSIONS: Our results are concordant with previous assumptions about serotonin dysfunction in depressives who attempt suicide.<p /><p>Language: en</p>",
language="en",
issn="0302-282X",
doi="10.1159/000086175",
url="http://dx.doi.org/10.1159/000086175"
}